thymic disease complicated by Sjogren's syndrome
Conditions
Sponsors
Tianjin Medical University General Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Patients with thymus disease confirmed by chest imaging; 2. Diagnosed with Sjogren's syndrome: in line with American College of Rheumatology (ACR)-European Union Against Rheumatism (EULAR) standards; 3. Aged >=18 years, no gender limit; 4. Subjects voluntarily join the study, agree to collect relevant clinical information, and sign an informed consent form.
Exclusion criteria
Exclusion criteria: 1. Accompanied by serious underlying diseases, such as liver and kidney failure, heart failure, etc.; 2. Patients with other systemic tumors; 3. Mental illness affects prognosis assessment; 4. According to the judgment of the investigator, there are other patients with concomitant diseases that seriously endanger the safety of the patient or affect the completion of the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Sjogren's Syndrome ESSDAI Score;Sjogren's Syndrome ESSPRI Score; | — |
Secondary
| Measure | Time frame |
|---|---|
| Severity of fatigue;Serum IgG, IgM, IgA, IgE;Complement levels of serum C3, C4;Saliva flow rate;Schirmer test;autoantibody spectrum;B cell activation markers;Blood routine examination;Liver function test;Renal tubular acidification function;Chest HRCT;Peripheral blood immune cell subsets; | — |
Countries
China
Contacts
Public ContactZhang Peng
Tianjin Medical University General Hospital
Outcome results
None listed