The effect of preoperative inhalation of high concentration hydrogen on PD-L1 in tumor tissues of NSCLC patients and its mechanism

Status

Recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2100050755

Enrollment

Unknown

Registered

2021-09-04

Start date

2021-09-10

Completion date

Unknown

Last updated

2022-05-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Lung disease

Interventions

Control group:33.3%O2

Experimental group:33.3%O2+66.7%H2

Eligibility

Sex/Gender

All

Age

35 Years to 70 Years

Inclusion criteria

Inclusion criteria: 1. Patients undergoing elective thoracoscopic radical resection of lung cancer; 2. Aged 35-70 years; 3. ASA I-III grade; 4. BMI: 18-23 kg/m2; 5. The tumor was diagnosed for the first time and originated in the lung.

Exclusion criteria

Exclusion criteria: 1. Severe structural heart disease and arrhythmia; 2. Severe hypertension (>=190/90mmHg) without regular medication; 3. Have taken hormone drugs recently; 4. Participated in other clinical trials within 4 weeks; 5. The patient is difficult to cooperate due to various reasons.

Design outcomes

Primary

Measure	Time frame
programmed cell death-ligand 1;extracellular signal-regulated protein kinase;Transcription activator-1;	—

Secondary

Measure	Time frame
volume of drainage;extubation time;length of stay;lung function;	—

Countries

China

Contacts

Public ContactYang Wanchao

The Second Affiliated Hospital of Harbin Medical University

dachao_1980@126.com+86 13796636010

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026