Effects of optimal PEEP based on driving pressure-guided on lung protection in children requiring one-lung ventilation during thoracoscopic surgery.

Status

Recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2100050739

Enrollment

Unknown

Registered

2021-09-03

Start date

2021-09-15

Completion date

Unknown

Last updated

2022-05-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Thoracoscopic lobectomy

Interventions

control group:PEEP=5cmH2O

driving pressure group:optimal PEEP based on driving pressure-guided

Eligibility

Sex/Gender

Male

Age

2 Years to 8 Years

Inclusion criteria

Inclusion criteria: 1. Aged 2-8 years; 2. Elective thoracoscopic lobectomy; 3. Expected operation time >= 2 hours; 4. ASA II-III children; 5. The family members signed the informed consent.

Exclusion criteria

Exclusion criteria: 1. Unable to cooperate with the study for any reason or the investigator thinks that it is not suitable to be included in this trial; 2. Patients who underwent thoracoscopic surgery again during the hospitalization; 3. Preoperative mechanical ventilation patients; 4. History of acute lung injury or acute respiratory distress syndrome within 3 months before surgery; 5. Patients with severe abnormal liver and kidney function, abnormal lung function, and intracranial hypertension; 6. Participated in other clinical trials.

Design outcomes

Primary

Measure	Time frame
Lung compliance;Oxygenation index;Inflammatory index;	—

Countries

China

Contacts

Public ContactGu Haifei

Kunming Children's Hospital

550345980@qq.com+86 13529374907

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026