Comparison of opioid-free anesthesia and conventional general anesthesia in pneumonectomy

Status

Recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2100050738

Enrollment

Unknown

Registered

2021-09-03

Start date

2021-09-01

Completion date

Unknown

Last updated

2022-05-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Lung Cancer

Interventions

No opioid anesthesia group:Implement an opioid-free approach to general anesthesia

Traditional General Anesthesia Group:conventional general anesthesia

Eligibility

Sex/Gender

All

Age

18 Years to 65 Years

Inclusion criteria

Inclusion criteria: 1. Aged 18-65 years; 2. Under elective general anesthesia, receive thoracoscopic lung slices (including lung wedge resection, segmentectomy, lobectomy, and sleeve resection); 3. ASA classification: I-II; 4. BMI: 18.5 to 25kg/m2; 5. Patients voluntarily participated and signed the informed consent.

Exclusion criteria

Exclusion criteria: 1. Hypersensitivity to any anesthetics or other materials required during surgery; 2. Pregnant or breastfeeding; 3. Outpatient or emergency surgery; 4. Patients who have undergone transplantation or have a history of transplantation; 5. Patients with tumor metastasis; 6. Patients with atrioventricular block, intraventricular block or Adam-Stokes syndrome; 7. Patients who use beta-blockers for a long time or whose heart rate is lower than 50bpm; 8. Patients with dysfunction of heart, lung, liver, kidney and other organs; 9. Patients with cognitive impairment who cannot communicate.

Design outcomes

Primary

Measure	Time frame
Incidence of postoperative nausea and vomiting;	—

Secondary

Measure	Time frame
degree of postoperative nausea and vomiting (VAS score 0-10);use of rescue antiemetic;degree of postoperative pain (VAS score 0-10);times of the use of patient-controlled analgesia within 48h after surgery;use of rescue analgesics;highest heart rate and blood pressure within 3min after trachea intubation;the increased ratio of heart rate and blood pressure within 3 min after trachea intubation;duration from the termination of infusing anesthetics to extubation and the duration from the termination of infusing anesthetics to the moment when Aldrete score higher than 9;times of bradycardia ( 20%);duration of LOS in ICU and the total duration of hospitalization;	—

Measure

Time frame

degree of postoperative nausea and vomiting (VAS score 0-10);use of rescue antiemetic;degree of postoperative pain (VAS score 0-10);times of the use of patient-controlled analgesia within 48h after surgery;use of rescue analgesics;highest heart rate and blood pressure within 3min after trachea intubation;the increased ratio of heart rate and blood pressure within 3 min after trachea intubation;duration from the termination of infusing anesthetics to extubation and the duration from the termination of infusing anesthetics to the moment when Aldrete score higher than 9;times of bradycardia ( 20%);duration of LOS in ICU and the total duration of hospitalization;

—

Countries

China

Contacts

Public ContactWang Jiafeng

Shanghai Changhai Hospital

jfwang@smmu.edu.cn+86 21 31161869

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 6, 2026