Exploring the mechanism of changes in BIS and cerebral oxygen metabolism in patients undergoing arthroscopic knee surgery induced by ketamine based on metabolomics and network pharmacology

Status

Recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2100050693

Enrollment

Unknown

Registered

2021-09-02

Start date

2021-09-10

Completion date

Unknown

Last updated

2022-05-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Arthroscopic knee surgery

Interventions

Experimental group:Use esketamine

control group:Equal doses of saline

Eligibility

Sex/Gender

All

Age

18 Years to 59 Years

Inclusion criteria

Inclusion criteria: 1. Patients aged 18 to 59 years, regardless of gender; 2. Body mass index BMI18.5~23.9kg/m2; 3. Patients undergoing knee arthroscopy; 4. American Physician Association (ASA) grades I to II.

Exclusion criteria

Exclusion criteria: 1. Cardiovascular and cerebrovascular diseases such as hypertension; 2. Diabetes and other endocrine system diseases; 3. Metabolic diseases; 4. Mental illness; 5. Nervous system diseases; 6. History of traumatic brain injury, intracranial hypertension; 7. Cardiac insufficiency, atrial fibrillation, valve disease, severe arrhythmia; 8. Patients with obvious anemia (hemoglobin < 6.0g/l) and blood system diseases before surgery; 9. History of allergy to anesthetics; 10. Those who refuse to participate in this experiment and have incomplete information.

Design outcomes

Primary

Measure	Time frame
Bispectral index;	—

Countries

China

Contacts

Public ContactLin Chengxin

Guangxi Medical University

lin.chx@163.com+86 13907865980

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026