Analysis of relative factors of corneal sub-basal nerve morphological changes in ocular chronic graft-versus-host disease

Status

Recruiting

Phases

Early Phase 1

Study type

Observational

Source

ChiCTR

Registry ID

ChiCTR2100050686

Enrollment

Unknown

Registered

2021-09-02

Start date

2021-10-01

Completion date

Unknown

Last updated

2022-05-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Graft-versus-host disease

Interventions

GVHD group:None

Control group:None

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Patients who have received bone marrow hematopoietic stem cell transplantation; 2. She did not use ocular immunosuppressive therapy when she first visited Peking University Third Hospital.

Exclusion criteria

Exclusion criteria: 1. Patients with eye allergies, infections, glaucoma, retinopathy, acute GVHD or other systemic immune system diseases; 2. Patients with incomplete medical records or unable to cooperate with the examination; 3. Patients who have received ocular immunosuppressive therapy.

Design outcomes

Primary

Measure	Time frame
Ocular Surface Disease Index;Corneal fluorescein staining;Tear break-up time;Tear meniscus;Schirmer’s test;concentration of cytokines in tear;Intravital confocal microscopy;	—

Secondary

Measure	Time frame
visual acuity;Intraocular pressure;	—

Countries

China

Contacts

Public ContactHong Jing

Peking University Third Hospital

hongjing1964@sina.com+86 13910573646

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026