Significance of A33, EpCAM, CD62p, CD61 in endothelial and platelet-derived extracellular vesicles in the diagnosis and differential diagnosis of GVHD and TMA after HSCT

Status

Recruiting

Phases

Early Phase 1

Study type

Observational

Source

ChiCTR

Registry ID

ChiCTR2100050665

Enrollment

Unknown

Registered

2021-09-01

Start date

2021-08-31

Completion date

Unknown

Last updated

2022-11-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

HSCT

Interventions

Gold Standard:GVHD reference (Seattle BMT Center) was divided into 4 grades according to the severity of damaged tissue and symptoms

TA-TMA diagnostic criteria were performed according to TMA diagnostic criteria.

Index test:A33,&#32

EpCAM,&#32

CD62p,&#32

CD61

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Allogeneic hematopoietic stem cell transplantation patients.

Exclusion criteria

Exclusion criteria: Autotransplantation patient.

Design outcomes

Primary

Measure	Time frame
Epithelial cell adhesion molecule;P-selectin;Cluster of differentiation 61;SEN, SPE, ACC, AUC of ROC;	—

Countries

China

Contacts

Public ContactXiong Hao

Wuhan Children's Hospital, Tongji Medical College of Huazhong University of Science and Technology

22587481@qq.com+86 13006107360

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026