Canceration of oral leukoplakia
Conditions
Interventions
Gold Standard:Pathological diagnosis
(OCT 
OCM) 
Sponsors
Beijing Stomatological Hospital Affiliated to Capital Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. Test 1: (1) Men or women aged 18 to 70 years; (2) Biopsy pathological diagnosis of leukoplakia cancer; (3) Those who entered the Department of Head and Neck Oncology, Beijing Stomatological Hospital Affiliated to Capital Medical University after being confirmed by biopsy. 2. Test 2: (1) Men or women aged 18 to 70 years; (2) The clinical diagnosis of leukoplakia is ineffective after drug treatment or suspected of white spot cancer and needs to undergo excision or incision biopsy for pathological diagnosis.
Exclusion criteria
Exclusion criteria: 1. Test 1: (1) Patients with underlying diseases or other factors that cannot tolerate surgery; (2) Those with mental illness who cannot cooperate; (3) The preoperative lesion area has received radiotherapy, chemotherapy, laser, or the use of topical drugs in the lesion area within three months before surgery, and other treatment methods that affect the imaging effect of OCT/OCM; (4) Some other situations that the researchers think are inappropriate to participate. 2. Test 2: (1) Those who are accompanied by underlying diseases or other factors and cannot tolerate biopsy surgery; (2) Those with mental illness who cannot cooperate; (3) The preoperative lesion area has received radiotherapy, chemotherapy, laser, or the use of topical drugs in the lesion area within three months before surgery, and other treatment methods that affect the imaging effect of OCT/OCM; (4) Pregnant or lactating women; (5) Some other situations that the researcher considers inappropriate to participate.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Structural changes and boundaries of keratinized layer in oral leukoplakia;Is the continuity of the basement membrane of oral leukoplakia intact;Thickness changes of leukoplakia epithelium in oral mucosa;Changes of echo intensity of leukoplakia epithelium in oral mucosa;Morphological changes of oral leukoplakia epithelial cells;SEN, SPE, ACC, AUC of ROC; | — |
Countries
China
Contacts
Public ContactHuang Xin
Beijing Stomatological Hospital Affiliated to Capital Medical University
Outcome results
None listed