severe traumatic brain injury
Conditions
Interventions
cholinesterase
combined 
with 
Gold Standard:Clinical outcome
Sponsors
Affiliated Hospital of Xuzhou Medical University
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. A clear history of craniocerebral injury, and CT examination was performed on admission to confirm the diagnosis; 2. Aged over 18 years; 3. The time interval from injury to ICU admission is less than 24 hours; 4. Post-traumatic GCS score 3 days.
Exclusion criteria
Exclusion criteria: 1. Previous neurological diseases such as cerebral hemorrhage and cerebral infarction; 2. Hemorrhagic shock accompanied by severe trauma in other parts; 3. There is a history of infection or antibiotics within 2 weeks before admission; 4. Long-term use of steroids or immunosuppressants; 5. Previous blood disease or autoimmune disease; and severe liver, kidney, heart, and lung insufficiency; 6. Previous malignant tumor, coronary heart disease, COPD, metabolic syndrome; 7. Pregnant and lactating women. 8. Subjects give up treatment during the trial; 9. Incomplete data, failed follow-up within 28 days.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Neutrophil lymphocyte ratio;cholinesterase;SEN, SPE, ACC, AUC of ROC, PPV, NPV; | — |
Countries
China
Contacts
Public ContactZhao Wenjing
Affiliated Hospital of Xuzhou Medical University
Outcome results
None listed