Pelvic organ prolapse
Conditions
Interventions
exposure group:None
nonexposure group:None
Sponsors
Peking Union Medical College Hospital, Chinese Academy of Medical Sciences
Eligibility
Sex/Gender
Female
Inclusion criteria
Inclusion criteria: 1. Transvaginal pelvic mesh implantation is planned for pelvic organ prolapse; 2. Uterine prolapse/fornix or vaginal anterior wall prolapse III-IV degree; 3. Protrusion of the posterior wall of the vagina I-II degree.
Exclusion criteria
Exclusion criteria: 1. Have sex or vaginal douching in the past 5 days, 2. Application of oral or vaginal antibiotics, antifungals, immunosuppressants, hormone drugs or probiotics in the past 30 days. 3. Combined with immunosuppressive diseases, combined with breast cancer, endometrial cancer and other complications that are contraindicated in the use of vaginal estrogen, 4. If the patient has a uterus before surgery and does not undergo transvaginal hysterectomy at the same time, 5. Intraoperative bladder injury or intraoperative bleeding >500ml or postoperative hematoma.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Host gene expression; | — |
Secondary
| Measure | Time frame |
|---|---|
| Vaginal microbiome;Protein expression in vaginal secretions; | — |
Countries
China
Contacts
Public ContactZhu Lan
Peking Union Medical College Hospital, Chinese Academy of Medical Sciences
Outcome results
None listed