stress ulcer
Conditions
Interventions
Topical HA treatment group:Topical use of HA
Cold-saline control group:Topical use of cold-saline
Blank control group:None
Sponsors
Tianjin Medical University General Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. Hematemesis or melena for the first time, and the occult blood test of gastric juice was positive; 2. At least one major risk factor for bleeding from stress ulcer present within 24 h. The major risk factors expected to be the cause of considerable physiological stress were major head injury with or without chest, abdomen, solid organ, spinal cord, or limb trauma; sudden cerebrovascular event; and major surgery; 3. Clinical condition requiring NICU hospitalization and clinical condition requiring gastric tube in place for more than 48 h.
Exclusion criteria
Exclusion criteria: 1. Significant risk of swallowing blood; 2. Contraindication to placement of an orogastric tube; 3. GBS score >= 6; 4. Enrollment in another clinical study with an HA component within 7 days prior to enrollment in this study; 5. Known or suspected allergic reaction to HA.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| vital signs;Risk factor assessment;Creatinine clearance;To detect Hb and HCT in Bleeding time; | — |
Countries
China
Contacts
Public ContactXuejun Yang
Tianjin Medical University General Hospital
Outcome results
None listed