Novel Coronavirus Pneumonia (COVID-19)
Conditions
Interventions
Case series:Nil
Sponsors
Food and Health Bureau - Health and Medical Research Fund
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Group 1: (n=30) Confirmed (recently diagnosed) subjects fulfilling laboratory criteria. Group 3: (n=350) Convalescent cases (original strain, 2020)*. Group 4: (n=1600) Subjects with epidemiological link to COVID-19, who meet the CHP reporting criteria of COVID-19, inbound travellers under compulsory quarantine at designated places. Group 5: (n=100) Healthy Subjects with no history of DED or probable/confirmed COVID-19. Group 6a: (n=100) Confirmed (recently diagnosed) subjects fulfilling laboratory criteria (Omicron strain, 2022) recruited from the community. Group 6b: (n=100) Confirmed (recently diagnosed) subjects fulfilling laboratory criteria (Omicron strain, 2022) recruited from hospitals. Group 7: (n=100) Subjects with long-COVID systemic complications. Group 8a: (n=100) Subjects with no history of probable/confirmed COVID-19 and pre-existing primary DED. Group 8b: (n=100) Convalescent subjects with pre-COVID primary DED. Group 9a: (n=100) Subjects with no history of probable/confirmed COVID-19 and pre-existing secondary DED. Group 9b: (n=100) Convalescent subjects with pre-COVID secondary DED.
Exclusion criteria
Exclusion criteria: 1. Mentally not fit for consent; 2. Patients with recent (< 6 months) pneumonia or COVID19 cannot be recruited as healthy control.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Descriptive statistics of the clinical, demographic and ophthalmic data;Concordance rate on RT-PCR results between ocular and respiratory samples by Kendall's Coefficient of Concordance; | — |
Secondary
| Measure | Time frame |
|---|---|
| Correlation of ophthalmic data with RT-PCR by mixed linear regression model;Serial viral load changes in positive ocular samples by serial paired t-test;Longitudinal ophthalmic data from patients with positive findings; | — |
Countries
China
Contacts
Public ContactDr Chong Kam Lung Kelvin
Department of Ophthalmology and Visual Sciences, CUHK
Outcome results
None listed