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Clinical study of dexmedetomidine for brain protection in patients undergoing cardiac surgery under different extracorporeal circulation temperatures

Clinical study of dexmedetomidine for brain protection in patients undergoing cardiac surgery under different extracorporeal circulation temperatures

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2100050574
Enrollment
Unknown
Registered
2021-08-29
Start date
2021-09-01
Completion date
Unknown
Last updated
2022-05-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Patients undergoing cardiac surgery under extracorporeal circulation

Interventions

Experimental group:Dexmedetomidine
Control group:normal saline

Sponsors

Tangshan Gongren Hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 75 Years

Inclusion criteria

Inclusion criteria: 1. Aged 18 to 75 years; 2. No severe liver and kidney insufficiency.

Exclusion criteria

Exclusion criteria: 1. Patients with coronary heart disease and myocardial infarction; 2. Those with immune system diseases; 3. Those who suffer from blood system diseases; 4. Those who use glucocorticoids before surgery; 5. Preoperative Mini Mental State Scale (MMSE) score < 23 and those with cognitive decline before surgery; 6. Long-term use of sedatives, antidepressants, and alcoholism.

Design outcomes

Primary

MeasureTime frame
Cognitive function;—

Secondary

MeasureTime frame
blood brain-derived neurotrophic factor;neuron-specific enolase;S-100ß protein;glial fibrillary acidic protein;mRNA407-5p;Superoxide dismutase;Malondialdehyde;total antioxidant capacity;—

Countries

China

Contacts

Public ContactSun Peng

Tangshan Gongren Hospital

32298830@qq.com+86 18833303388

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026