periodontitis
Conditions
Interventions
Experimental group1:Rinse with povidone iodine rinse
Experimental group2:Rinse with compound chlorhexidine rinse
Control group:Rinse with saline
Sponsors
West China Stomatological Hospital of Sichuan University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Aged 18 to 65 years, no gender limitation; 2. There are at least 20 natural teeth in the mouth, and the Ramfjord index teeth (i.e. 16 teeth, 21 teeth, 24 teeth, 36 teeth, 41 teeth, 44 teeth) are natural teeth and have no missing and non-residual roots; 3. Attachment loss at the most severe interproximal site: 1-4mm; bone loss on imaging: 1/3 of the root and coronal (0-33%); no tooth loss due to periodontitis. Local complexity: maximum probing depth <= 5mm, mainly in patients with periodontitis with horizontal bone loss; 4. Must have good vision, physical movement and judgment ability; 5. Voluntarily participate in the trial and comply with the clinical trial requirements.
Exclusion criteria
Exclusion criteria: 1. Those who are allergic to iodine and other drugs related to this test; 2. Pregnant women and lactating women; 3. Those who have undergone periodontal treatment such as scaling and scaling within the past 3 months; 4. Those who have used hormones, antibiotics and other drugs within the past 2 weeks; 5. Liver function damage (ALT or AST >= 1.5 times the upper limit of normal); 6. Patients with renal insufficiency (Crea exceeds the upper limit of the normal value or Urea >= 1.5 times the upper limit of the normal value); 7. Abnormal thyroid function, blood disease, acute viral stomatitis, traumatic ulcer, neuropsychiatric system and other diseases; 8. The subjects participated in other clinical trials at the same time and did not reach the clinical endpoint; the subjects participated in other clinical trials within the past 3 months; 9. Other investigators believe that they are not eligible for inclusion.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| bleeding index;plaque index;stain index; | — |
Secondary
| Measure | Time frame |
|---|---|
| pocket probe depth;clinical attachment loss;Markers of gingival crevicular fluid inflammation;Supragingival plaque microorganisms;Evaluation of subjects' satisfaction after medication; | — |
Countries
China
Contacts
Public ContactDing Yi
West China Stomatological Hospital of Sichuan University
Outcome results
None listed