fungal keratitis
Conditions
Interventions
experimental group:Continuous Infusion of Voriconazole combined with topical medication therapy
control group:topical medication therapy
Sponsors
The Second Xiangya Hospital, Central South University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Consecutive patients who sought treatment for smear-positive,culture-positive,gene chip-proved or IVCM-proved corneal ulcers with visual acuity of 20/80 (0.54 logarithm of the minimum angle of resolution [logMAR]) or worse were screened. 2. Understand and agree to the treatment protocol in the trial, be willing to accept hospitalization, and be able to follow up.
Exclusion criteria
Exclusion criteria: 1. Evidence of concomitant infection with herpes or bacteria. 2. Impending or frank perforation or limbal involvement. 3. Ageyounger than 18 years or older than 80 years. 4. Corneal scarring is indistinguishable from corneal ulcer. 5. In pregnancy or lactation. 6. Allergy to the drug used. 7. The eye had undergone a corneal transplant.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| cure rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| the size of epithelial defect;the size of stromal infiltration or scar;corrected visual acuity;duration of healing;epithelial healing time;the depth of stromal infiltration or scar; | — |
Countries
China
Contacts
Public ContactChen Bai-Hua
The Second Xiangya Hospital, Central South University
Outcome results
None listed