coal workers' pneumoconiosis
Conditions
Interventions
Experimental group1:Pirfenidone
Experimental group2:Tetrandrine
Experimental group3:Bromhexine Hydrochloride
Experimental group4:Mass lung lavage
Control Group:None
Sponsors
The First Hospital of Shanxi Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. Aged 18 to 70 years (including 18 years and 70 years), gender is not limited; 2. Have a clear occupational history, in line with GBZTO-2015 "Diagnosis of Occupational Pneumoconiosis"; 3. The disease is in a stable stage, with symptoms of respiratory impairment, decreased exercise tolerance, and limited daily activities; 4. Able to complete pulmonary function test; 5. The patients voluntarily participated in this trial, with good compliance, and had the ability to understand and sign the informed consent form before the study.
Exclusion criteria
Exclusion criteria: 1. ALT or AST > 3 times ULN; 2. TBiL>1.5 times ULN; 3. Creatinine clearance rate <30 mL/min; 4. Acute respiratory infection; 5. Patients with other clinically significant abnormalities in the lungs; 6. Hypersensitivity to the test drug or its components; 7. Patients with severe cardiovascular disease; 8. Patients with mental illness; 9. Those who have participated in clinical trials of other drugs within 3 months; 10. Those who are judged by the investigator to be unfit to participate in the trial.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Pulmonary fuction test; | — |
Secondary
| Measure | Time frame |
|---|---|
| Questionaire survey data;Imaging data; | — |
Countries
China
Contacts
Public ContactZhang Xinri
The First Hospital of Shanxi Medical University
Outcome results
None listed