Wilson's disease
Conditions
Interventions
Control group:Normal Saline
Experimental group:Dexmedetomidine
Sponsors
The First Affiliated Hospital of Anhui University of Chinese Medicine
Eligibility
Sex/Gender
All
Age
16 Years to 58 Years
Inclusion criteria
Inclusion criteria: 1. Aged 16 to 58 years; 2. There is a definite diagnosis of WD before surgery, with indications for splenectomy; 3. Child-Pugh grade A~B; 4. The preoperative American Society of Anesthesiologists (ASA) disease classification was I-II; 5. Agree to sign the informed consent form for this study.
Exclusion criteria
Exclusion criteria: 1. Have a history of mental illness or long-term use of psychotropic drugs; 2. History of long-term use of opioids or other analgesics; 3. Preoperative MMSE score <= 23 points; 4. Illiterate patients; 5. Patients with communication disorders cannot complete cognitive function tests.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Postoperation pain;Postoperative delirium;Cognitive impairment; | — |
Secondary
| Measure | Time frame |
|---|---|
| Interleukin 1 beta;Interleukin 6;Tumor necrosis factor-alpha; | — |
Countries
China
Contacts
Public ContactWang Shouyi
The First Affiliated Hospital of Anhui University of Chinese Medicine
Outcome results
None listed