Parkinson's Disease
Conditions
Interventions
Experimental group:real TMS+speech therapy+exercise training
Control group:sham TMS+speech therapy+exercise training
Sponsors
The First Affiliated Hospital of Sun Yat-Sen University
Eligibility
Sex/Gender
All
Age
50 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Diagnosed with primary Parkinson's disease (H-Y stage 1.5-3); 2. Aged 50 to 80 years; 3. Diagnosed with primary Parkinson's disease (H-Y stage 1.5-3) by neurology department; 4. Right-handed, native language Chinese, no professional vocal or instrumental training; 5. Hearing is basically normal, cognitive function is generally normal, and he has not received speech therapy before; 6. Except for Parkinson's disease, no other nervous system disease or mental disease; 7. There is no need to adjust the medication regimen within 1 month after enrollment.
Exclusion criteria
Exclusion criteria: 1. Have a history of epilepsy; 2. There are pacemakers in the body or metal implants in the brain, ears or metal implants in other parts of the body; 3. Has claustrophobia.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| acoustic responses amplitude;Magnetic Resonance - Functional Connectivity;Parkinson's Composite Rating Scale; | — |
Secondary
| Measure | Time frame |
|---|---|
| voice handicap index;Event-related potential P2 component;stand-up test;Berg balance scale; | — |
Countries
China
Contacts
Public ContactLiu Hanjun
The First Affiliated Hospital of Sun Yat-Sen University
Outcome results
None listed