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Clinical study on the effect of preventive analgesia with nerve block on neurocognitive function after hip fracture surgery in elderly patients

Clinical study on the effect of preventive analgesia with nerve block on neurocognitive function after hip fracture surgery in elderly patients

Status
Recruiting
Phases
Early Phase 1
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2100050537
Enrollment
Unknown
Registered
2021-08-28
Start date
2021-09-01
Completion date
Unknown
Last updated
2022-05-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Hip fracture in elderly patients

Interventions

Experimental group:subarachnoid block
Control Group:quadratus lumborum block

Sponsors

Affiliated Hospital of Jiangsu University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
65 Years to No maximum

Inclusion criteria

Inclusion criteria: 1. Patients who are scheduled for elective surgical treatment of hip fractures, the types of surgery include total hip replacement or hemi-hip replacement, PFNA (proximal femoral anti-rotation intramedullary nail fixation), American Society of Anesthesiologists (ASA) grade II to III ; 2. Aged >= 65 years, BMI 18-25; 3. Exercise VAS score > 3 points, agree to receive preventive analgesia; 4. Voluntary participation in research.

Exclusion criteria

Exclusion criteria: 1. Significant cognitive impairment was found in the preoperative visit (MMSE score (see Table 2) illiterate < 17 points, primary school < 20 points, junior high school and above <24 points); 2. History of hip surgery; 3. History of opioid or alcohol abuse; 4. History of chronic pain; 5. Nervous system diseases; 6. Severe visual impairment; 7. Anemia (Hb < 80g/L), coagulation disorder; 8. Inability to communicate effectively with doctors; 9. Lost to follow-up; 10. Patients with underlying diseases such as heart failure, severely reduced respiratory function, severe arrhythmia, poorly controlled hypertension and diabetes before surgery.

Design outcomes

Primary

MeasureTime frame
Neuron specific enolase;

Countries

China

Contacts

Public ContactJiang Peng

Affiliated Hospital of Jiangsu University

doctorjp@163.com+86 13914556527

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026