The diagnostic value of peripheral blood PTGS2 in perioperative neurocognitive dysfunction of elderly patients undergoing hip replacement

Status

Recruiting

Phases

Early Phase 1

Study type

Observational

Source

ChiCTR

Registry ID

ChiCTR2100050533

Enrollment

Unknown

Registered

2021-08-28

Start date

2021-08-21

Completion date

Unknown

Last updated

2022-05-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Perioperative neurocognitive dysfunction

Interventions

Gold Standard:Clinical outcome

Index test:peripheral&#32

blood&#32

PTGS2

Eligibility

Sex/Gender

All

Age

65 Years to No maximum

Inclusion criteria

Inclusion criteria: 1. Aged >= 65 years, gender is not limited; 2. ASA classification I-III; 3. Hip replacement under general anesthesia; 4. Preoperative MMSE score: illiteracy>17 points, primary school>20 points, middle school and above>24 points; 5. Informed consent of patients and their families.

Exclusion criteria

Exclusion criteria: 1. Cognitive dysfunction disease existed before surgery; 2. There is serious damage to important organs such as heart, lung, liver and kidney; 3. Patients who cannot cooperate with the completion of blood sample collection or cognitive function evaluation; 4. Patients who take drugs that affect cognitive function for a long time; 5. Patients who refuse to participate or cannot communicate.

Design outcomes

Primary

Measure	Time frame
prostaglandin endoperoxide synthase 2;	—

Countries

China

Contacts

Public ContactFeng Lan

Affiliated Hospital of Southwest Medical University

fenglan2162@163.com+86 18380976032

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026