Alzheimer's Disease
Conditions
Interventions
Alzheimer's dementia group:Nil
Amnestic mild cognitive impairment group:Nil
Parkinson's disease group:Nil
normal control group:Nil
Sponsors
The Affiliated Brain Hospital of Nanjing Medical University
Eligibility
Sex/Gender
All
Age
60 Years to 80 Years
Inclusion criteria
Inclusion criteria: Observation group A: 1. Alzheimer's disease (AD) patients; 2. Diagnosed by a psychiatrist, in line with the criteria for AD in the U.S. Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-V). Observation group B: 1. Elderly patients with depression, older than 60 years old; 2. Diagnosed by a psychiatrist, in line with the International Diagnostic and Statistical Manual of Mental Disorders 10th Edition (ICD-10) diagnostic criteria for depression. Observation group C: 1. Amnestic mild cognitive impairment (aMCI) patients; 2. Diagnosed by a psychiatrist, in line with Petersen's diagnostic criteria; 3. The chief complaint or insider reports cognitive impairment; 4. Poor performance on neuropsychological tests of episodic memory, with impairment in one or more cognitive domains (executive function, memory, language, or visuospatial); 5. Normal activities of daily living; 6. The diagnosis of dementia has not been reached. Observation group D: 1. Parkinson's disease patients; 2. Diagnosed by a neurologist, in line with the diagnostic criteria of "Chinese Parkinson's Disease Diagnostic Criteria" (2016 edition). Control group: The normal population with no cognitive function and no emotional disorder matched with the experimental group was assessed by a psychiatrist.
Exclusion criteria
Exclusion criteria: 1. Best corrected visual acuity (BCVA) ±4D; 2. Eye axis length 26mm; 3. OCTA imaging quality 21mmHg; 5. Gonioscopy: the angle is closed; 6. Macular degeneration: macular degeneration, epiretinal membrane or hole; 7. Other retinopathy: such as retinal vein occlusion or fundus atrophy; 8. Eye diseases such as glaucoma, optic atrophy or uveitis; 9. History of eye surgery or laser, history of eye trauma within 12 months after cataract surgery; 10. History of diabetes, hypertension, cardiovascular or cancer.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| vessel density; | — |
Secondary
| Measure | Time frame |
|---|---|
| Ocular axis length; | — |
Countries
China
Contacts
Public ContactMei Gang
The Affiliated Brain Hospital of Nanjing Medical University
Outcome results
None listed