Difficult Airway
Conditions
Interventions
Experimental group1:remimazolam (ED50 dose, dose determined by part I test)
Experimental group2:remimazolam (ED95 dose, dose determined by part II test)
Control group:dexmedetomidine(1 µg/?)
Sponsors
Guangxi Medical University College of Stomatology
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: First part: 1. ASA I-II grade; 2. Aged 18 to 65 years; 3. Body mass index (BMI)<=30 ?/m2; 4. Suspected difficult airway patients: mouth opening <= 2 cm, and it is expected to be difficult to ventilate without a mask. Second part: 1. ASA I-II grade; 2. Aged 18 to 65 years; 3. Body mass index (BMI)<=30 ?/m2; 4. Patients with identified difficult airway.
Exclusion criteria
Exclusion criteria: First part: 1. Patients who are expected to have difficulty in mask ventilation; 2. Patients with a long-term history of taking sedatives or drug use before surgery; 3. Patients with severe heart, lung, liver, and kidney diseases before surgery, or those with obvious abnormal blood routine and blood biochemical indicators; 4. Those who are allergic to anesthetics. Second part: 1. Patients with a long-term history of taking sedatives or drug use before surgery; 2. Patients with severe heart, lung, liver, and kidney diseases before surgery, or those with obvious abnormal blood routine and blood biochemical indicators; 3. Those who are allergic to anesthetics.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| sedation success rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| Mean arterial pressure ;serum adrenalin;endotracheal intubation time;comfort score;comfort score;success rate of intubation; | — |
Countries
China
Contacts
Public ContactChen Qiumiao
Guangxi Medical University College of Stomatology
Outcome results
None listed