None listed
Conditions
Interventions
Experimental group:Receive FUWAI-SAVE system for cardiopulmonary bypass
Control group:Receive conventional cardiopulmonary bypass system
Sponsors
Fuwai Hospital, Chinese Academy of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Open heart surgery under cardiopulmonary bypass caused by various etiologies; 2. Aged >= 18 years; 3. The blood transfusion risk stratification score (Appendix 2) is 61-80 points; 4. Subjects signed written informed consent.
Exclusion criteria
Exclusion criteria: 1. Participated in other clinical trials within 1 month, and has been assessed to have a greater impact on this research; 2. Weight < 40kg; 3. Those who have a history of allergies to extracorporeal circulation pipelines and blood recovery equipment in the past; 4. Heart transplantation or combined heart-lung transplantation; 5. Perform emergency surgery; 6. Perform a second thoracotomy; 7. Perform hybrid surgery; 8. Perform major vascular surgery requiring deep hypothermic cardiopulmonary bypass; 9. Patients with mental illness or medical history, drug addicts, AIDS, syphilis, hepatitis B, hepatitis C virus positive patients; 10. Those with severe anemia, infection, tumor, active bleeding, severe liver, lung, and kidney disease; 11. Other circumstances judged by the investigator to be unsuitable for enrollment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| red blood cell transfusion; | — |
Secondary
| Measure | Time frame |
|---|---|
| platelet transfusions;fresh frozen plasma infusion;hemoglobin;C reactive protein;anticoagulation tests;neutrophil extracellular trap;angiopoietin;inflammatory factors;the incidence of major complications during pericardial circulation;inhospital mortality;mechanical ventilation time;ICU time;hospital stay;chest drainage;ICU cost;inhospital cost; | — |
Countries
China
Contacts
Public ContactJi Bingyang
Outcome results
None listed