Acute gastroenteritis in adults
Conditions
Interventions
Intervention group:Routine treatment and Saccharomyces boulardii 500mg/d
Control group:Conventional treatment and placebo 500mg/d
Sponsors
Tongji Medical College, Huazhong University of Science and Technology
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. The patient agrees to participate in the trial and signs the informed consent; 2. The patient has >= 3 stool samples within 24 hours; 3. The duration of the patient's diarrhea is less than 72 hours; 4. Aged >=18 years.
Exclusion criteria
Exclusion criteria: 1. There is indwelling vascular access (risk of bacteremia); 2. Being receiving immunosuppressive therapy or a known history of immunodeficiency (risk of bacteremia); 3. Oral or gastrointestinal surgery in the first 7 days (risk of bacteremia); 4. Critically ill patients (risk of bacteremia); 5. Blood in the stool in the past 72 hours, potentially serious chronic gastrointestinal problems or inflammatory bowel disease: excluding constipation, gastroesophageal reflux or chronic pain; 6. Patients during lactation or pregnancy; 7. Symptoms are caused by excessive drinking or taking drugs; 8. Use of probiotics, prebiotics or synbiotics in the first 4 weeks: but those who eat food containing the above ingredients are not excluded; 9. Received antibiotic treatment within the first 4 weeks; 10. Allergies to Saccharomyces boulardii or placebo ingredients (maltodextrin); 11. Previously included in this trial or participated in other trials at the same time; 12. No daily follow-up by phone or internet, or recent travel/business trip plans.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Duration of diarrhea;Total effective rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| Number of diarrhea;Number of vomiting;Vomiting duration;Abdominal pain score;Duration of abdominal pain;Modified Vesikari Score (MVS);Peripheral blood mononuclear cells;Inflammatory factors;Adverse reactions;Intestinal flora; | — |
Countries
China
Contacts
Public ContactTang Yuhan
Tongji Medical College, Huazhong University of Science and Technology
Outcome results
None listed