Pruritus
Conditions
Interventions
Experimental group:Preventive giving of 0.5ug/kg of namefene postoperatively
Control group:Normal saline
Sponsors
Fudan University Zhongshan Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Voluntary participation, the patient himself understands and signs the informed consent form; 2. Aged 18-80 years; 3. Patients who undergo surgery and voluntarily undergo epidural and postoperative analgesia; 4. In line with epidural analgesia indications: normal coagulation function; platelets >=75x10^9/L.
Exclusion criteria
Exclusion criteria: 1. Systemic infection state or the presence of foci of infection at the puncture site; Improper discontinuation of anticoagulant and antiplatelet agents; circulatory erratics; Those who suffer from mental illness and cannot cooperate; People with limb autonomy impairment; 2. The success of the epidural operation is uncertain due to trauma, deformity, implants, low back pain, etc. at the puncture site; 3. Those with serious abnormalities in the function of important organs before surgery; 4. Patients who cannot understand and cannot safely use an epidural analgesia pump; 5. Lack of expression and comprehension ability, unable to communicate effectively, do not understand the degree of itching and analgesia scorer; 6. Patients with a history of allergy to nalmefen injection before surgery; 7. Previous itching symptoms: patients with skin history, gout history, rheumatic immune diseases; 8. Those who are allergic to antibiotics, anesthetics or latex during the perioperative period; 9. Patients who have received allogeneic blood transfusion in the past 1 month; 10. Patients with serious complications in the perioperative period.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| the incidence of pruritus 24h after the surgery; | — |
Secondary
| Measure | Time frame |
|---|---|
| the first reported time point of pruritus;The patient's postoperative sleep quality;other anesthesia/analgesia related side effects;the severity of the acute pain postoperatively;the severity of pruritus postoperatively; | — |
Countries
China
Contacts
Public ContactFang Fang
Fudan University Zhongshan Hospital
Outcome results
None listed