Unexplained Infertility
Conditions
Interventions
Group A: Letrozole + gonadotropin
Group B:Gonadotropin
Sponsors
The First Affiliated Hospital of Nanjing Medical University / Jiangsu Provincial Hospital
Eligibility
Sex/Gender
Female
Age
20 Years to 37 Years
Inclusion criteria
Inclusion criteria: 1. Aged 20-37 years; 2. Normal ovulation (including BBT biphasic or B-ultrasound) or regular menstrual cycle (21-35 days); 3. Bilateral fallopian tubes are unobstructed (confirmed by lipiodol imaging or ultrasound salpingography or laparoscopy, only one side is unobstructed but not unobstructed); 4. The man's semen is routinely normal; 5. Both husband and wife agree to conduct outpatient ovulation induction + artificial insemination; 6. No artificial insemination before; 1 year without contraception and no pregnancy, over 35 years old without contraception but not pregnant for 6 months.
Exclusion criteria
Exclusion criteria: 1. Patients diagnosed with abnormal uterine cavity morphology (confirmed by three-dimensional B-ultrasound or hysteroscopy), including uterine malformations (mediastinal uterus, unicornuate uterus, double uterus), submucosal uterine fibroids or intrauterine adhesions; 2. Other diseases that may cause infertility, such as hyperprolactinemia, uncontrolled thyroid dysfunction, polycystic ovary syndrome, ovarian insufficiency (AMH30kg/m^2; 10. IUI contraindications to TCT or HPV results (report within 1 year).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Live birth rate;The incidence of ovarian hyperstimulation syndrome; | — |
Secondary
| Measure | Time frame |
|---|---|
| Clinical pregnancy rate;Multiple follicular rate;Incidence of twins and multiple births;Pregnancy loss rate;Ectopic pregnancy rate;Pregnancy and perinatal complications; | — |
Countries
China
Contacts
Public ContactLiu Jinyong, Wang Jing
The First Affiliated Hospital of Nanjing Medical University / Jiangsu Provincial Hospital
Outcome results
None listed