Insomnia, depression, subthreshold depression, mild cognitive impairment
Conditions
Interventions
subthreshold depression group:Nil
healthy control group:Nil
Sponsors
Shenzhen Hospital of Beijing University of Traditional Chinese Medicine (Longgang)
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Insomnia inclusion criteria: (1) Meet the diagnostic criteria of western medicine for insomnia; (2) Aged 18-80 years; (3) Consciousness, clear thinking, and use of language to communicate; (4) Pittsburgh Sleep Quality Index > 5; (5) The subjects voluntarily participate in the clinical trial and sign the informed consent form, and the procedure meets the requirements of GCP. 2. Depression included in the case criteria: (1) Meet the diagnostic criteria for depression; (2) Gender is not limited, aged >= 18 year; (3) Able to independently complete the questionnaire, give informed consent and participate voluntarily. 3. Subthreshold depression included in the case criteria: (1) Meet the diagnostic criteria for subthreshold depression, the Central Epidemiological Survey Depression Scale (CES-D) score >= 16 points, and the Hamilton Depression Scale (HAMD-17) score: 7 points = 18 years; (3) Able to independently complete the questionnaire, give informed consent and participate voluntarily. 4. Mild cognitive impairment included in the case criteria: (1) Meet the MCI diagnostic criteria; (2) MoCA score < 26, if the years of education <= 12 years, add 1 point to the score; (3) Aged between 50 and 80 years; (4) Sign the informed consent.
Exclusion criteria
Exclusion criteria: 1. Exclusion criteria for insomnia cases: (1) All systemic diseases such as pain, fever, cough, surgery, etc., as well as insomnia caused by external environmental interference factors; (2) Severe mental illness that affects sleep, such as: schizophrenia, bipolar disorder, paranoid disorder, schizoaffective disorder, mental disorder caused by epilepsy, and severe mental retardation; (3) Those who are pregnant, breastfeeding and those who plan to become pregnant; (4) Those who are allergic to aromatic drugs or have a history of severe adverse reactions, and those with severe allergic constitution; (5) Those with other serious diseases of the circulatory system, hematopoietic system, digestive system, endocrine system, etc.; (6) Those who are participating in clinical trials of other drugs. 2. Subthreshold depression and exclusion criteria for depression: (1) Patients with previous psychotic disorder or organic mental disorder; (2) Depressive episodes caused by psychoactive substances and non-addictive substances; (3) Those who are pregnant, breastfeeding and those who plan to become pregnant; (4) Known history of alcoholism, drug addiction or other drug abuse; (5) The patient has a strong suicide attempt or behavior; (6) Patients who refuse to complete the collection of any observational index. 3. Exclusion criteria for mild cognitive impairment: (1) Dementia patients or those taking anti-dementia drugs; (2) Cognitive impairment caused by acute cerebrovascular disease, brain atrophy, thyroid, anemia, inflammation, etc.; (3) Have a history of severe alcohol or drug abuse; (4) Cognitive impairment caused by depression; (5) Cognitive dysfunction due to other reasons such as poisoning or drugs.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Infrared thermal imaging image;Temperature value of each part;Tongue image; | — |
Countries
China
Contacts
Public ContactHan Zhenyun
Shenzhen Hospital of Beijing University of Traditional Chinese Medicine (Longgang)
Outcome results
None listed