Kennedy's disease (KD)
Conditions
Interventions
Experimental group:Leproterrine was injected subcutaneously
Sponsors
Shanghai Sixth People's Hospital
Eligibility
Sex/Gender
All
Age
30 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. Have the following clinical symptoms: muscle weakness, atrophy, tongue muscle atrophy, fibrillation, bulbar palsy or hand tremor; 2. Androgen receptor gene CAG repeat sequence length >= 38 times; 3. Aged between 30-70 years; 4. Patients who have no desire to have children; 5. The patient or family members signed the informed consent.
Exclusion criteria
Exclusion criteria: 1. Patients who are allergic to leuprolide and have serious complications; 2. Have used drugs that interfere with androgen levels within 8 weeks before informed consent; 3. The presence of other diseases associated with dysphagia, such as stroke, motor neuron disease, myasthenia gravis, diffuse idiopathic skeletal hyperplasia, cancer and other previously diagnosed neuromuscular diseases.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Luteinizing hormone;Follicle-stimulating hormone;Testosterone; | — |
Countries
China
Contacts
Public ContactLuan Xinghua
Shanghai Sixth People's Hospital
Outcome results
None listed