Postoperative Cognitive Dysfunction (POCD)
Conditions
Interventions
Fluoxetine group:Take 20 mg fluoxetine orally, from 8 weeks before the surgery to one day before the surgery
Placebo group:Take placebo orally, from 8 weeks before the surgery to one day before the surgery.
Sponsors
Fujian Provincial Hospital
Eligibility
Sex/Gender
All
Age
65 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Aged >= 65 years; 2. American Society of Anesthesiologists classification I-III.
Exclusion criteria
Exclusion criteria: 1. Minimal Mental State Examination (MMSE) score 3 times the upper limit of the standard) or renal damage (glomerular filtration rate <=60ml min^-1*1.73 m^-2). 7. Other investigators deem it inappropriate to be included in the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of postoperative cognitive dysfunction; | — |
Secondary
| Measure | Time frame |
|---|---|
| Area under curve of NRS pain score (at rest and movement);The quailty of recovery after surgery;Incidence of postoperative delirium;Postoperative cumulative opioid consumption;Anxiety and depression;C-reactive protein;IL-1ß;Sleep;Hospitalisation time; | — |
Countries
China
Contacts
Public ContactYao Yusheng
Fujian Provincial Hospital
Outcome results
None listed