Pain
Conditions
Interventions
Group A:Remifentanil TCI: 2 ng/ml, and tonic stimulation
Group B:Remifentanil TCI: 4 ng/ml, and tonic stimulation
Sponsors
Department of Anesthesiology, Shenzhen People's Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Subjects voluntarily sign the informed consent of this study; 2. Age between 18 and 65 years old, gender is not limited, weight kg=(height cm-100)±15%; 3. ASA I and II; 4. For surgical patients who need elective surgery under general anesthesia and need endotracheal intubation, surgery is required for non-emergency inpatients who have received appropriate preoperative preparation, with 1-2 hours of non-craniotomy and non-thoracotomy;Patients undergoing elective general anesthesia and requiring endotracheal intubation; 5. Subjects can follow the drug dosage and visit plan; 6. The systolic blood pressure (SBP) was 90-140 mmHg, and the diastolic blood pressure (DBP) was less than 90 mmHg; Body temperature = 100 g/L), platelet (>=75x10^9/L), white blood cell (3-15 x1 0^9/L); (2) Urine routine: urine protein (= 32 g/L; (4) Renal function: BUN and Cr were within the normal reference range; (5) Blood glucose: fasting blood glucose (FPG, 3.0-8.9 mmol/L or 55-160 mg/dL); (6) Blood lipid: total cholesterol (TC < 7.75 mmol/L or 300 mg/dL) and triglyceride (TG < 3.42 mmol/L or 300 mg/dL); (7) Electrolytes: Na^+ (130 ~ 150 mmol/L), K^+ (3.0 ~ 5.5 mmol/L), Ca^2+ (2.0 ~ 2.9 mmol/L).
Exclusion criteria
Exclusion criteria: 1. Those who are judged by the anesthesiologist to be unsuitable to participate in this trial; 2. Chronic pain with long-term use of analgesics, psychiatric drugs (including opioids, NSAIDs, sedatives, antidepressants), alcohol abuse; 3. Abnormal surgical anesthesia recovery history; 4. Suffer from esophageal reflux disease; 5. Sedatives, antiemetic drugs and antipruritic drugs were used 24 hours before surgery; 6. Difficult intubation is expected; 7. Have a history of opioid allergy; 8. Take monoamine oxidase inhibitors or antidepressants within 15 days; 9. Shock patients; 10. COPD patients; 11. Pregnant or parturient women; 12. Participated in other drug trials within three months; 13. Sponsors or researchers directly involved in the trial or their family members; 14. The researcher believes that there is any reason why the candidate cannot be selected.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Nociceptive index;Blood pressure;Heart rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| Bispectral index;SPO2; | — |
Countries
China
Contacts
Public ContactWu Chaoran
Department of Anesthesiology, Shenzhen People's Hospital
Outcome results
None listed