Intracranial infection/Pulmonary infection
Conditions
Interventions
Intracranial infection group:Carrimycin tablets 400mg/day for 8 days
Pulmonary infection group:Carrimycin tablets 400mg/day for 8 days
Sponsors
Shanghai Sixth People's Hospita
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. Patients in Neurocritical Care Unit; 2. Patients who meets the diagnostic criteria for intracranial or pulmonary infection according to the consensus of clinical diagnosis and treatment; 3. Patients who were confirmed CRO Infection: Carbapenem-resistant E.coli, Klebsiella pneumoniae, Pseudomonas aeruginosa and Acinetobacter Bowman were detected in cerebrospinal fluid or respiratory secretions; 4. Age 18 to 70 years(including boundary values), male and female; 5. The subject or legal representative agrees to receive treatment and voluntarily signs an informed consent form.
Exclusion criteria
Exclusion criteria: 1. Patients allergic to study drug or active ingredients; 2. Patients whose condition can not be reversed or who are in a terminal state; 3. Patients with bloodstream infection; 4. Patients with severe liver dysfunction and who have a Child-pugh score of C; 5. Patients with severe renal impairment (Creatinine Clearance Rate < 30 ml/min); 6. Severe gastrointestinal dysfunction that may affect the intake, transport or absorption of the drug being studied; 7. Join in a clinical trial of any drug or medical device within one month, or within 5 half-lives of other experimental drugs before screening; 8. Combined with other antibiotics that can bind to the 50s subunit of the ribosome to inhibit protein synthesis, including chloramphenicol, lincomycin and macrolides; 9. Pregnant and lactating women, subjects (both women and men) had family planning during the next six months; 10. Other conditions that the researchers considered unsuitable for study participation.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Temperature;Clearance rate of carbapenem-resistant Organism;Cerebrospinal fluid test (white blood cell count, sugar content, protein);Microbiological examination (sputum, urine, cerebrospinal fluid culture); | — |
Secondary
| Measure | Time frame |
|---|---|
| C-reactive protein and procalcitonin;Infection indicators such as the percentage of white blood cells and neutrophils;Imaging evaluation of the severity of infection; | — |
Countries
China
Contacts
Public ContactChen Hao
Shanghai Sixth People's Hospital
Outcome results
None listed