Patients with mechanical ventilation in ICU
Conditions
Interventions
Experimental group:Remazolam toluene sulfonate was given+normal saline
Control group:Normal saline
Sponsors
The First Affiliated Hospital of Air Force Military Medical University
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1.For ICU patients with mechanical ventilation, the expected duration of ventilators assisted ventilation is >=24h; 2.Age >=18 years; 3.Invasive blood pressure monitoring; 4.No benzodiazepines and a2 receptor agonists were used within 24h; 5.Sign the informed consent.
Exclusion criteria
Exclusion criteria: 1.Treatment with neuromuscular blockers; 2.High spinal cord injury, moderate and severe craniocerebral injury; 3.Shock state or use of vasoactive drugs; 4.Pregnant women, alcohol or drug dependent persons; 5.Study drug allergy or other contraindication; 6.Participated in other clinical trials within 3 months.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Maximum change of blood pressure after sputum suction; | — |
Secondary
| Measure | Time frame |
|---|---|
| Mean arterial pressure, heart rate, oxygen saturation;Asphyxiation cough response score;Behavioral pain scale score; | — |
Countries
China
Contacts
Public ContactSu Binxiao
The First Affiliated Hospital of Air Force Military Medical University
Outcome results
None listed