Effects of optimal PEEP based on driving pressure-guided on lung protection in 3-12 months infant under laparoscope radical operation on megacolon disease

Status

Active, not recruiting

Phases

Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2100050325

Enrollment

Unknown

Registered

2021-08-26

Start date

2021-09-01

Completion date

Unknown

Last updated

2022-04-25

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

laparoscope radical operation on megacolon disease

Interventions

C group:PEEP=5cmH2O

P group:Optimal PEEP based on driving pressure-guided

Eligibility

Sex/Gender

Male

Age

No minimum to 1 Years

Inclusion criteria

Inclusion criteria: 1.Aged 3 to 12 months; 2.Selective laparoscopic megacolon surgery; 3.Operation time >= 2 hours; 4.ASA classification II-III; 5.Written inform consent of family members.

Exclusion criteria

Exclusion criteria: 1.Cannot cooperate for any reason or not suitable for investigator; 2.Re-laparoscopic surgery during hospitalization; 3.Patient who has done preoperative mechanical ventilation; 4.Acute lung injury or acute respiratory distress syndrome history within 3 months before operation; 5.Patients with severe liver and kidney dysfunction, lung dysfunction, and intracranial hypertension; 6.Other clinical trials participation.

Design outcomes

Primary

Measure	Time frame
Respiratory mechanical index;Index of gas exchange efficiency;inflammatory index;Lung injury marker;Pulmonary complication index;	—

Countries

China

Contacts

Public ContactGu Haifei

Kunming Children's Hospital

550345980@qq.com+86 13529374907

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026