Meibomian gland dysfunction
Conditions
Interventions
Vectored thermal pulsation:Vectored thermal pulsation
Intense pulsed light and meibomian gland expression:Intense pulsed light and meibomian gland expression
Control:Eyelid warm compress therapy
Sponsors
Food and Health Bureau
Eligibility
Sex/Gender
Male
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. >=18 years of age with no upper age limit; 2. Agree to attend follow-up visits and comply to treatment regimen 3. Symptomatic dry eye TFBUT =13; 4. Mild to moderate (level 3-4) MGD on at least one eye; 5. Fitzpatrick skin type 1-4.
Exclusion criteria
Exclusion criteria: 1.Contact lens wear 3 months before or during the study period; 2.Use of topical (including anti-glaucomatous, cyclosporin, antibiotics) or systemic medication known to affect (worsen or improve) MGD 3 months before or during the study period; 3.Major systemic (e.g. Sjogren’s syndrome), dermatologic (e.g. Rosacea) known to affect MGD or ocular conditions (including thyroid eye disease, recurrent conjunctivitis, ocular allergies); 4.Ocular procedures (excluding uncomplicated cataract operation) 3 months before and any ocular procedure during the study period; 5.History of vision correction surgery or plan to undergo the procedure during the study period; 6.Dermatological treatment (including chemical peeling, laser, IPL or energy device in the periocular and facial region) 6 months before or during the study period; 7.Contraindications to IPL therapy (including recent sun-burn, photosensitivity, active or pigmented skin lesions, cancer, implants, tattoos, semi-permanent makeup in the periocular area); 8.Contraindications to VTP therapy (ocular surgery, ocular injury, ocular herpes of eye or eyelid, and ocular inflammation 3 months before the study; active ocular infection, etc.); 9.Women who are pregnant, nursing, planning pregnancy, or of childbearing potential not using a reliable method of contraception.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Tear film breakup time (TFBUT); | — |
Secondary
| Measure | Time frame |
|---|---|
| Serial measurements of MG;Tear-film related parameters;Intraocular pressure;Compliance to EW;Factors associated with MGD outcomes and treatment related complications; | — |
Countries
China
Contacts
Public ContactDr Chong Kam Lung Kelvin
Department of Ophthalmology and Visual Sciences, CUHK
Outcome results
None listed