Thyroid disease
Conditions
Interventions
L1 group:1mg/kg/h lidocaine
L2 group:1.5mg/kg/h lidocaine
L3 group:2mg/kg/h lidocaine
S group:Normal saline
Sponsors
The Affiliated Hospital of Xuzhou Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1.ASA classification I~II; 2.Aged 18 to 70 years; 3.Elective general anesthesia for thyroid surgery under tracheal intubation; 4.Signed informed consent; 5.Smoking cessation status; 6.45kg < weight <100Kg.
Exclusion criteria
Exclusion criteria: 1.Cough, hoarseness, sore throat before surgery; 2.Upper respiratory tract infection; 3.Expect difficulty in intubation; 4.History of allergy to amide local anesthetics; 5.Al-Si's syndrome (acute cardiogenic cerebral ischemia syndrome), pre-excitation syndrome, severe heart block; 6.Use of steroid hormones; 7.The operation duration was more than 4h; 8.Cervical lymph node dissection; 9.Other contraindications to surgery or anesthesia 10.Include other interventional studies.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The incidence of sore throat 24 hours after surgery; | — |
Secondary
| Measure | Time frame |
|---|---|
| Incidence of choking, hoarseness, hypoxemia, expectoration, dyspnea;Intraoperative dosage of remifentanil;Visual analog score of sore throat;Visual analog scores of incision pain, resting pain and motor pain;Incidence of nausea and vomiting;The 15-item recovery quality Score scale was evaluated;Brice questionnaire score;Perioperative fatigue scale scores; | — |
Countries
China
Contacts
Public ContactZhang Maoyin
The Affiliated Hospital of Xuzhou Medical University
Outcome results
None listed