esophageal stenosis after ESD
Conditions
Interventions
Control group:Hormone treatment was started on the third day after ESD and lasted for 8 weeks
Experimental group:Collagen membrane was covered on the wound after ESD, and titanium clip was fixed. Oral hormones were taken from the third day after ESD, and the course of treatment was 8 weeks
Sponsors
Nanjing Drum Tower Hospital, the Affiliated Hospital of Nanjing University Medical School
Eligibility
Sex/Gender
All
Age
20 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1.Aged 20 to 70 years; 2.Pathologically confirmed low-grade, high-grade intraepithelial neoplasia or carcinoma in situ of the esophagus; 3.The primary tumor was located in the thoracic esophagus; 4.The depth of tumor invasion was determined to be inside the epidermis or mucosa under endoscopy; 5.CT confirmed no lymph node metastasis, no distant metastasis to the neck, chest and abdomen; 6.The lesion range was more than 3/4 weeks or the whole circumference of the esophagus, and the length diameter was <=5cm under endoscopy; 7.Dysphagia score <0 (Dysphagia score: 0 can eat normally; 1 point no solid food; 2 points can eat half stream; 3 points can only consume liquid; 4 points no fluid.); 8.Organ function is good; 9.Voluntarily signed the informed consent.
Exclusion criteria
Exclusion criteria: 1.Complicated with other malignant tumors; 2.Present infection requires systemic treatment; 3.Body temperature >=38?; 4.Pregnant, possibly pregnant, within 28 days after delivery or during lactation; 5.Severe mental illness; 6.Patients who need to take anticoagulant or antiplatelet aggregation drugs for a long time; 7.Hypertension patients with poor control; 8.Patients with unstable angina within 3 weeks or acute myocardial infarction within 6 months; 9.Peptic ulcer; 10.Glaucoma, posterior capsular opacity or corneal herpes; 11.A history of surgical operation within 3 months; 12.Hepatitis B surface antigen/surface antibody or core antibody positive; 13.T-SPOT was positive; 14.Prednisone, PPI allergy; 15.A history of radiotherapy for neck, chest wall, lung and mediastinum; 16.A history of esophageal and mediastinal operations.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of postoperative stenosis after endoscopic submucosal dissection; | — |
Secondary
| Measure | Time frame |
|---|---|
| The average number of balloon dilations required under endoscope;Dysphagia score;Supplementary scale for patients with esophageal cancer; | — |
Countries
China
Contacts
Public ContactZou Xiaoping
Nanjing Drum Tower Hospital, the Affiliated Hospital of Nanjing University Medical School
Outcome results
None listed