Type 1 diabetes
Conditions
Interventions
Treatment group:Autologous umbilical cord blood transfusion
Sponsors
Sun Yat-sen Memorial Hospital, Sun Yat-sen University
Eligibility
Sex/Gender
All
Age
1 Years to 18 Years
Inclusion criteria
Inclusion criteria: 1.Aged 1 to 18 years; 2.Meets the diagnostic criteria of T1DM according to the 2020 ADA guidelines, and stores autologous umbilical cord blood; 3.At least one of the following islet autoantibodies is positive: islet cell antibody, insulin autoantibody, tyrosine phospholipase antibody, glutamic acid decarboxylase antibody; 4.Autologous cord blood, and >=30ml; 5.The whole blood cell count, liver and kidney function and electrolyte are in the normal range; 6.Willing to obey the comprehensive management of diabetes.
Exclusion criteria
Exclusion criteria: 1.Any complex medical problems affecting umbilical cord blood transfusion and follow-up monitoring; 2.Long-term use of corticosteroids or other immunosuppressants to treat other diseases; 3.Suffer from a variety of chronic infectious or immunodeficiency diseases, such as hepatitis B, hepatitis C, AIDS, syphilis, tuberculosis, etc.; 4.With any acute infectious disease, such as respiratory infection, intestinal infection, skin infection, etc., if you still want to participate in this study, you need to control the infection for at least a week.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Blood glucose control;Insulin dosage;Islet ß cell function index; | — |
Secondary
| Measure | Time frame |
|---|---|
| Immunological index;Diabetic complication;Anthropometric indicators;Security index; | — |
Countries
China
Contacts
Public ContactLiang Liyang
Sun Yat-sen Memorial Hospital, Sun Yat-sen University
Outcome results
None listed