perioperative neurocognitive impairment
Conditions
Interventions
Experimental group:After induction of conventional anesthesia protocol, 0.2mg/kg/h esmketamine was injected intravenously
Sponsors
The First Affiliated Hospital of Jinan University
Eligibility
Sex/Gender
All
Age
60 Years to No maximum
Inclusion criteria
Inclusion criteria: 1.Willing to participate and able to provide informed consent; 2.The duration of operation was more than 2 hours in patients undergoing non-cardiac, non-neurosurgical, and non-gastrointestinal open surgery under general anesthesia in our hospital; 3.Aged >= 60, ASA I~III, BMI 18-30 kg / m^2; 4.There was no clinical trial of other drugs in 3 months before screening.
Exclusion criteria
Exclusion criteria: 1.Patients who are allergic to active ingredients or all excipients of esketamine; 2.Unable to complete neuropsychological test (including severe visual or hearing impairment) or MMSE 180/100mmhg); 5.Combined with other important organ dysfunction: including severe liver and kidney dysfunction; brain organic lesions, such as tumor vascular disease or arteriovenous malformation, stroke, dementia, and other histories; Cardiac insufficiency (NYHA >= grade III); 6.Emergency, cardiac or intracranial surgery patients; 7.The patients were hospitalized within 3 months; 8.Patients with a history of alcohol, drug dependence, or abuse; 9.Patients with a history of mental illness such as bipolar disorder, severe depression, schizophrenia, or dementia; 10.Patients with difficult follow-up or poor compliance.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| delirium;cognitive function;subjective sleep quality; | — |
Secondary
| Measure | Time frame |
|---|---|
| postoperative cognitive dysfunction;postoperative extubation time;monitor the treatment room stay time after postoperative anesthesia;inflammatory cytokines level ;faecal microbiota composition;the amount of anesthetic drugs used during the operation;intraoperative vasoactive drug dosage;postoperative pain during hospitalization;depression;anxiety; | — |
Countries
China
Contacts
Public ContactLi Yalan
The First Affiliated Hospital of Ji'nan University
Outcome results
None listed