Efficacy and safety of dopamine infusion for prevention of hypotension after induction of general anesthesia combined with dexmedetomidine in elderly patients undergoing noncardiac surgery

Status

Active, not recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2100050306

Enrollment

Unknown

Registered

2021-08-26

Start date

2022-02-01

Completion date

Unknown

Last updated

2022-04-25

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

hypotension

Interventions

DA group:Dexmedetomidine is combined with dopamine

NE group:Dexmedetomidine+Norepinephrine

C group:Dexmedetomidine+normal saline

Eligibility

Sex/Gender

All

Age

65 Years to No maximum

Inclusion criteria

Inclusion criteria: 1.65 years or older; 2.American Anesthesiologists (ASA) I-II; 3.Scheduled for elderly non-cardiac patients undergoing elective noncardiac surgery with endotracheal tube intubation; 4.Body mass index (BMI) >=18 and <=30kg/m^2; 5.Able to understand the research process and methods, and voluntarily participate in this research.

Exclusion criteria

Exclusion criteria: 1.Emergency surgery; 2.Preoperative hypotension (systolic blood pressure <90mmHg); 3.Difficult to establish intravenous access; 4.Cardiac arrhythmias (tachyarrhythmias, bradyarrhythmias, and ventricular arrhythmias); 5.Suspected or diagnosed myocardial ischemia; 6.Preoperative medication; 7.History of psychotropic drug use.

Design outcomes

Primary

Measure	Time frame
the incidence of hypotension;	—

Secondary

Measure	Time frame
blood pressure variability;norepinephrine recovery rate;atropine recovery rate;	—

Countries

China

Contacts

Public ContactTian Lei

Zigong First People's Hospital

tlnc1990@163.com+86 18882004170

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026