Postpartum Depression
Conditions
Interventions
es-ketamine group:es-ketamine 0.5mg/kg used in patient controlled intravenous analgesia
control group:normoal PCIA used after cesarean but no es-ketamine
Sponsors
Henan Provincial People's Hospital
Eligibility
Sex/Gender
Female
Age
18 Years to 40 Years
Inclusion criteria
Inclusion criteria: 1. Sign the informed consent form; 2. No previous history of depression and brain diseases; 3. Full-term and singleton pregnant women undergoing cesarean section under selective subarachnoid anesthesia; 4. ASA classification I, II; 5. BMI 18~30 kg/m2
Exclusion criteria
Exclusion criteria: 1. Patients who refuse to sign informed consent; 2. Those who have contraindications to subarachnoid anesthesia; 3. Patients with intractable, refractory hypertension or severe cardiovascular disease; 4. Patients with previous history of depression, and patients who have received or have not received antidepressant treatment; 5. Severe pathological obstetric conditions (pregnancy hypertension syndrome, eclampsia, placenta previa, placental abruption, etc.); 6. Those who are known to be allergic to the drugs used during surgery.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| incidence of postpartum depression; | — |
Secondary
| Measure | Time frame |
|---|---|
| Edinburgh Postnatal Depression Scale (EPDS);Ramssy Sedation Scale Score;Visual Analogue Scale (VAS);incidence of side reacton; | — |
Countries
China
Contacts
Public ContactJiaqiang Zhang
He'nan Provincial People's Hospital
Outcome results
None listed