Radical resection of pulmonary carcinoma
Conditions
Interventions
experimental group:Remazolam Toluenesulfonate
control group:Propofol
Sponsors
The First Affiliated Hospital of Nanchang University
Eligibility
Sex/Gender
All
Age
18 Years to 85 Years
Inclusion criteria
Inclusion criteria: 1. Male or female subjects, aged from 18 to 65 years, more than 5 years of education; 2. For patients undergoing thoracoscopic lobectomy and undergoing one-lung ventilation during operation, the operation time is expected to exceed 1.5 hours; 3. ASA grade I-II, and deep vein and radial artery puncture should be done during operation; 4.The score of mini-mental examination (MMSE) before operation was >=21 points.
Exclusion criteria
Exclusion criteria: 1. Allergic to benzodiazepines and allergic to other narcotic drugs; 2. Severe pulmonary ventilation, pulmonary ventilation dysfunction, poor lung function before operation, inability to tolerate one-lung ventilation, severe COPD, pulmonary encephalopathy and severe cor pulmonale before operation; 3. Systolic blood pressure < 90mmHg in quiet state or poor control of hypertension with antihypertensive drugs, sinus bradycardia or atrioventricular block before operation, severe arrhythmia, angina pectoris, diabetes, anemia, acute lung infection, liver and kidney insufficiency; 4. Patients who have taken other clinical trial drugs in the last 4 months; 5. Lactating women during pregnancy; 6. Severe arrhythmia and angina pectoris, smoking and quitting time less than 2 weeks, long-term alcoholism, drug abuse, taking sedatives, taking antidepressants; 7. Severe cerebrovascular diseases are suffering from central nervous system diseases, psychosis, psychological diseases, long-term drug treatment and recent neurosurgery.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Blood gas analysis;Hemodynamics;Pulmonary function;Min-i mental state examination;BIS;IL-8;IL-6;SOD;MDA; | — |
Countries
China
Contacts
Public ContactWei Fusheng
The First Affiliated Hospital of Nanchang University
Outcome results
None listed