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Correlation between clinical effect of caffeine citrate on apnea in preterm infants and adenosine receptor gene polymorphism

Correlation between clinical effect of caffeine citrate on apnea in preterm infants and adenosine receptor gene polymorphism

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2100050212
Enrollment
Unknown
Registered
2021-08-22
Start date
2021-09-01
Completion date
Unknown
Last updated
2022-04-25

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

apnea in preterm infants

Interventions

Caffeine response group versus caffeine non-response group:Nil

Sponsors

Xiamen Maternal and Child Care Hospital, Women and Children's Hospital, School of Medicine, Xiamen University
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: 1. Preterm infants with gestational age < 34W who were admitted to NICU immediately after birth and treated with caffeine citrate within 24h after birth were delivered in the hospital.

Exclusion criteria

Exclusion criteria: 1. Severe intracranial hemorrhage (Grade 3-4); 2. Congenital malformation or chromosomal abnormality; 3. Genetic metabolic disease; 4. Neonatal sepsis; 5. Serious lung lesions such as: pneumothorax, bronchial lung dysplasia, severe lung infection, atelectasis, etc.

Design outcomes

Primary

MeasureTime frame
Clinical effect of caffeine on apnea;Adenosine receptor genotype;—

Countries

China

Contacts

Public ContactLin Xinzhu

Xiamen Maternal and Child Care Hospital, Women and Children's Hospital, School of Medicine, Xiamen University

xinzhufj@163.com+86 13328312516

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026