Azoospermia
Conditions
Interventions
Gold Standard:Microscopic Sperm Surgery to Obtain Sperm
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Sponsors
Shandong University
Eligibility
Sex/Gender
Male
Age
18 Years to 58 Years
Inclusion criteria
Inclusion criteria: 1. Meet the diagnostic criteria of NOA: According to the "Human Semen Examination and Sperm-Cervical Mucus Interaction Laboratory Manual", no less than 3 routine semen examinations indicate that no sperm can be found after centrifugation and microscopy. At the same time, follow European Urology As required by the Associations Male Infertility Guidelines, NOAs diagnosis is based on standard clinical examination procedures, including medical history, physical examination, routine semen analysis, seminal plasma biochemical examination, serum reproductive hormone analysis, ultrasound evaluation, chromosome karyotype analysis and Y chromosome analysis Microdeletion detection, etc.; 2. All NOA subjects did not receive conventional medical treatment; 3. Agreed to undergo microscopic sperm extraction, and there were no related surgical contraindications; 4. Healthy control group age-matched with NOA, healthy The clinical evaluation and semen parameters of the male reproductive system in the control group were all within the normal range.
Exclusion criteria
Exclusion criteria: 1. Patients with obstructive azoospermia; 2. Patients with hypogonadotropic syndrome; 3. Patients with chromosomal abnormalities; 4. Patients with AZFa region or AZFb region deletion; 5. Cryptorchidism Patients with secondary azoospermia caused by viral orchitis, varicocele, pituitary diseases, and systemic diseases.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Sperm retrieval rate;Testosterone;Follicle stimulating hormone; | — |
Countries
China
Contacts
Public ContactGuo Li
Shandong University
Outcome results
None listed