Rapid sequence induction
Conditions
Interventions
experimental group:Transnasal Humidified Rapid-Insufflation Ventilatory Exchange
control group:Facemask
Sponsors
Nanjing First Hospital
Eligibility
Sex/Gender
All
Age
65 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Patients undergoing endotracheal intubation under rapid sequence induction under general anesthesia; 2. Aged >= 65 years; 3. ASA classification I-III; 3. Mallampati classification I-II; 4. Have a clear sense of THRIVE; 5. Meet ethical requirements.
Exclusion criteria
Exclusion criteria: 1. Patients with suspected or definite difficult airway; 2. Diseases of the central nervous system; 3. Unable to ventilate with face mask; 4. Serious cardiovascular, pulmonary, liver or kidney disease; 5. Patients with abnormal epistaxis and nasopharyngeal space; 6. Patients with moderate or above anemia; 7. BMI>30kg/m2 8. Patients enrolled in other studies within 30 days; 9. Other researchers considered it inappropriate to participate in this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| PaO2 after 5min preoxygenation (T1);Safe apneic time (from the beginning of laryngoscope to the time when SpO2 drops to 95% or the time when safe apneic time reaching 8min); | — |
Secondary
| Measure | Time frame |
|---|---|
| General information and airway assessment;Intubation time;PaCO2?SpO2?HR?MAP after patients entered the room(T0), 5min after preoxygenation (T1), immediately after successful intubation (T2), safe apniec time reached 8 min or SpO2 decreased to 95%(T3);Manual assisted respiration and use of vasoactive drugs;Cough, reflux, aspiration, aspiration pneumonia and other complications after anesthesia induction;The number of cases with safe apneic time reached 8 min and SpO2>=95%;First mechanical ventilation PETCO2 after intubatio;Minimum SpO2 after facemask ventilation ceases;PaO2 after patients entered the room(T0), immediately after successful intubation (T2), safe apniec time reached 8 min or SpO2 decreased to 95%(T3); | — |
Countries
China
Contacts
Public ContactWang Xiaoliang
Nanjing First Hospital
Outcome results
None listed