The effect of frequency effect of brain-computer interface intervention on upper limb functional outcome after stroke and its mechanism

Status

Active, not recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2100050162

Enrollment

Unknown

Registered

2021-08-19

Start date

2022-01-01

Completion date

Unknown

Last updated

2022-04-25

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

stroke

Interventions

BCI high-frequency treatment group:High-frequency BCI assisted upper limb function training (frequency: 30 minutes each time, once a day, 12 times in total)

BCI low frequency treatment group:Low-frequency BCI assisted upper limb function training (frequency: 30 minutes each time, once every other day, 12 times in total)

Control group:Regular upper limb function training (frequency: 30 minutes each time, once a day, 12 times in total)

Eligibility

Sex/Gender

All

Age

50 Years to 75 Years

Inclusion criteria

Inclusion criteria: 1. Meet the diagnostic criteria of stroke formulated by the fourth National Conference on Cerebrovascular Diseases; 2. Cerebral apoplexy confirmed by brain CT or MRI, disease course >=6 months; 3. Stroke caused one hand dysfunction, and Brunnstrom stage 1-3; 4. Montreal Cognitive Assessment, MoCA>=26; 5. Aged from 50 to 75 years; 6. Right-handedness prevails; 7. Voluntarily sign informed consent.

Exclusion criteria

Exclusion criteria: 1. Previous history of upper limb fracture, deformity of upper limb, etc; 2. The condition is unstable or the condition changes occur during the experiment, which affects the experimental results; 3. Unable to complete the experiment due to serious heart, lung, liver and kidney and other important organ diseases; 4. Severe cognitive dysfunction or aphasia; 5. Suffering from serious mental disorders; 6. Taking medications that reduce the threshold of seizures; 7. Any implanted device or metal may be affected by the magnetic field generated by TMS.

Design outcomes

Primary

Measure	Time frame
Functional near infrared spectroscopy;Motor evoke potential;	—

Secondary

Measure	Time frame
Action Research Arm Test (ARAT);Wolf motor function test;Fugl-Meyer assessment-upper limb;Modified Barther Index;Montreal Cognitive Assessment, MoCA;	—

Countries

China

Contacts

Public ContactZhang Yanni

The Fifth Affiliated Hospital of Guangzhou Medical University

yannizhang0828@gzhmu.edu.cn+86 13544482014

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026