Alzheimer's disease (AD)
Conditions
Interventions
20HZ group:20HZ Transcranial Magnetic Stimulation
iTBS group:TBS Transcranial Magnetic Stimulation
Sponsors
The Affiliated Brain Hospital of Guangzhou Medical University
Eligibility
Sex/Gender
All
Age
55 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Aged 55-80 years; 2. Clinically diagnosed as possible AD according to NINCDS-ADRDA criteria; 3. MMSE score >=10 points and <=24 points; 4. CDR score is 0.5-2 points; 5. Before the baseline period, use a stable dose of cholinesterase inhibitor or memantine; 6. The patient himself and his family were informed and signed the informed consent.
Exclusion criteria
Exclusion criteria: 1. Those with clinical features or pathological changes (such as visual hallucinations, Parkinson's syndrome, motor neuron disease, asymmetric dystonia and myoclonus, ataxia, etc.) suggesting dementia types other than AD (such as dementia with Lewy bodies, frontotemporal dementia, corticobasal degeneration, Creutzfeldt-Jakob disease, etc.); 2. Those who have a history of major head trauma or mental and nervous system diseases (such as severe depression); 3. Patients with major physical diseases such as heart, liver, and kidney cannot tolerate this study; 4. Received MECT treatment within three months; 5. Those who have a history of epilepsy or a first-degree relative with a history of epilepsy or other neurological diseases; 6. Contraindications for MRI examination and TMS treatment: with cardiac pacemaker, neurostimulator, artificial metal heart valve, intracranial aneurysm clip, intraocular metal foreign body, cochlear implants and other metal implants (except oral braces); pregnancy, claustrophobia, history of epilepsy.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Alzheimer's Disease Rating Scale - Cognitive Score; | — |
Secondary
| Measure | Time frame |
|---|---|
| Simple Mental State Examination Scale Score;Neuropsychiatric Scale Score;Activities of Daily Living Scale Score;Clinical Dementia Rating Scale Score;Hamilton Anxiety Scale Score;Hamilton Depression Scale Score; | — |
Countries
China
Contacts
Public ContactNing Yuping
The Affiliated Brain Hospital of Guangzhou Medical University
Outcome results
None listed