Cerebral vascular disease
Conditions
Interventions
Experimental group:drug + interventional therapy
Sponsors
People's Hospital of Guangxi Zhuang Autonomous Region
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Aged 18-80 years; 2. Symptomatic: cerebral infarction or TIA related to occluded blood vessels, cognitive impairment or monocular vision loss, etc.; 3. Hemodynamics: There is no forward blood flow signal in the internal carotid artery or middle cerebral artery confirmed by vascular imaging examination (TIMI grade is 0); 4. CT or MRI perfusion imaging indicates insufficient perfusion in the responsible vessel area; 5. The occlusion time to the interventional treatment time exceeds 24 hours; 6. The patient or legal representative signs the consent form.
Exclusion criteria
Exclusion criteria: 1. Both anterior circulation arteries were occluded; 2. Moyamoya disease; 3. DSA confirmed the occlusion from the C1 segment of the internal carotid artery to the M1 segment of the middle cerebral artery; 4. Intracranial hemorrhage in the past 3 months; 5. Obvious disability before the disease (mRS>3 points); 6. Known severe allergy to iodine contrast agents and other drugs (heparin, aspirin, clopidogrel, statin lipid-lowering drugs, etc.) (rashes are not counted) or unable to use iodine contrast agents and other drugs (heparin, aspirin, clopidogrel, statin lipid-lowering drugs, etc.) for various reasons; 7. The surgical instrument cannot reach the target blood vessel due to tortuous approach or other difficulties; 8. There is a history of major surgery within the recent 1 month, or the albumin is less than 18mg/L; 9. Active bleeding or known bleeding tendency, platelet count less than 50x10^9/L; 10. Combined with severe heart, liver, renal insufficiency or other serious advanced diseases; 11. Life expectancy is less than 1 year; 12. Other special circumstances are not suitable for participating in this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| modified Rankin score; | — |
Countries
China
Contacts
Public ContactHe Guoyong
People's Hospital of Guangxi Zhuang Autonomous Region
Outcome results
None listed