Type 2 diabetes mellitus (T2DM)
Conditions
Interventions
Placebo group:metformin combined with placebo
Probiotic group:metformin combined with compound probiotics
Sponsors
Inner Mongolia People's Hospital
Eligibility
Sex/Gender
All
Age
20 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Diagnosed as ''T2DM'', in line with ADA/WHO standards; 2. No gender limit, aged 20-65 years; 3. The duration of diabetes is >=3 months; 4. Simple diet control or oral metformin; or other drugs but discontinued for more than 3 months; 5. 6.5%<=glycated hemoglobin<=8.5%; 6. No antibiotics were taken 1 month before enrollment; 7. No history of chronic gastrointestinal diseases; 8. Those who agree to participate in this study and sign the written informed consent.
Exclusion criteria
Exclusion criteria: 1. Patients who are pregnant, breastfeeding, or planning to become pregnant within 6 months; 2. Patients with hepatic insufficiency: alanine aminotransferase and aspartate aminotransferase >= 2 times or more of the upper limit of the normal value; 3. Patients with renal insufficiency: Glomerular filtration rate (GFR)<=90ml/min; 4. Those suffering from endocrine diseases such as hypercortisolism and hyperthyroidism that affect glucose metabolism; 5. Severe organic diseases, including cancer, coronary heart disease, myocardial infarction or cerebral infarction; 6. Suffering from infectious diseases, including tuberculosis and AIDS; 7. Accompanied by severe DM complications (proliferative retinopathy, kidney damage above stage IV, diabetic foot infection and severe diabetic neuropathy); 8. Alcoholism.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Glycosylated hemoglobin;Blood glucose;Intestinal flora; | — |
Secondary
| Measure | Time frame |
|---|---|
| Blood uric acid;Blood lipids;Insulin; | — |
Countries
China
Contacts
Public ContactChen Ye
Inner Mongolia People's Hospital
Outcome results
None listed