Helicobacter pylori infection
Conditions
Interventions
Gold Standard:Actual eradication outcomes of Helicobacter pylori eradication using bismuth metronidazole-containing quadruple therapy
Index test:Can 
the 
inhibitory 
of 
metronidazole 
for 
eradication 
bismuth 
metronidazole-containing 
quadruple 
therapy
Sponsors
Peking University First Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. Aged 18-70 years. 2. Present infection of Helicobacter pylori (pass C13 breath test). 3. Meet the indications for Helicobacter pylori eradication (according to the Fifth National Consensus Report on the Treatment of Helicobacter pylori Infection). 4. Gastroscopy is planned according to clinical needs. 5. Those who have received Helicobacter pylori eradication therapy in the past need to stop the drug for more than 3 months before entering the group. 6. Metronidazole has never been used for eradication of Helicobacter pylori therapy. 7. Taking metronidazole for other purposes (such as oral treatment, gynecology, etc.) within 3 months before treatment for <7 days, or taking metronidazole for other purposes for more than 3 months before treatment <10 days.
Exclusion criteria
Exclusion criteria: 1. Patients with hypersensitivity to drugs used in the eradication regimen. 2. After gastric surgery. 3. Pregnant and lactating patients. 4. History of PPI, bismuth or antibiotic medication in the past 4 weeks. 5. Patients with severe liver, kidney, cardiac insufficiency, malignant tumor and cerebrovascular disease. 6. Patients who have received regular Helicobacter pylori eradication therapy within 3 months before treatment, or patients who have taken antibiotics one month before treatment (recent antibiotics before treatment may affect the efficacy of Helicobacter pylori eradication).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| minimal inhibitory concentration for metronidazole;mutation site for rdxA gene; | — |
Secondary
| Measure | Time frame |
|---|---|
| previous exposure for metronidazole;gastroscope diagnosis;previous eradication history;C13 breath test values; | — |
Countries
China
Contacts
Public ContactWang Weihong
Peking University First Hospital
Outcome results
None listed