To observe the effect of different collection volume of autologous platelet-rich plasma on blood protection during aortic dissection

Status

Active, not recruiting

Phases

Early Phase 1

Study type

Observational

Source

ChiCTR

Registry ID

ChiCTR2100050082

Enrollment

Unknown

Registered

2021-08-16

Start date

2021-09-01

Completion date

Unknown

Last updated

2022-04-25

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Group 1:The total blood volume collected was 15-20ml/kg

Group 2:The total blood volume collected was 30-40ml/kg

Eligibility

Sex/Gender

All

Age

18 Years to 65 Years

Inclusion criteria

Inclusion criteria: 1. ASA II-III class, NYHA cardiac function class II-III class; 2. Adults aged 18-65 years, not pregnant; 3. Aortic dissection surgery intended for deep hypothermic circulatory arrest and confirmed by the investigator to meet the criteria; 4. Sign the informed consent.

Exclusion criteria

Exclusion criteria: 1. Have a history of heart failure before surgery; 2. Coagulation dysfunction, hemoglobin <11mg/dL, platelets less than 10X10^9; 3. End-stage renal disease.

Design outcomes

Primary

Measure	Time frame
haematocrit;platelet count;prothrombin time;activated partial thromboplastin time;international normalized ratio;fibrinogen;thrombelastogram;	—

Secondary

Measure	Time frame
mean arterial pressure;heart rate;pulse oximetry saturation;bispectral index;regional cerebral oxygen saturation;central venous pressure;stroke volume variation;cardiac output;	—

Countries

China

Contacts

Public ContactTian Ayong

the First Affiliated Hospital of China Medical University

tay0626@126.com+86 13940182455

Outcome results